Threshold doses

It is important to determine the distribution of threshold doses of food allergens that are able to induce symptoms in patients with food allergy. More information about these threshold levels of different food allergens in combination with consumption patterns and quantities of allergen present in consumer products, will enable us to assess risks for patients with food allergy to experience allergic reactions after ingestion of consumer products.

To obtain information about threshold doses, double-blind placebo-controlled food challenges (DBPCFC) are conducted within the CFA. The last couple of years, emphasis has been on determining the threshold doses for several allergens using protein extracts, but also purified allergens from different allergenic foods. Threshold doses for eliciting allergic reactions in peanuts vary significantly between patients. Furthermore, because of various environmental or personal factors, the individual threshold dose prbably varies over time. However, overall, these sources of variability will be leveled out when investigating the distribution of threshold doses among a group of food allergic patients.

  • Wensing et al., The distribution of individual threshold doses elicting allergic reactions in a population with peanut allergy. J Allergy Clin Immunol 2002; 110(6):915-20
  • Flinterman et al., Determination of no-observed-adverse-effect levels and eliciting doses in a representative group of peanut-sensitized children. J Allergy clin Immunol 2006; 117(2):448-54